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Although glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are highly effective for body weight reduction, there remains a critical unmet need for complementary strategies that drive selective fat loss and sustain long-term weight reduction

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As previously noted, even the lowest effective 4mg aw dose provided compelling health benefits

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With antiamyloid antibodies Leqembi (lecanemab) and Kisunla (donanemab) now FDAapproved for early Alzheimers, attention is turning to combination strategies that address multiple disease pathways