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Among patients with UC, those treated with GLP1RA had lower rates of corticosteroid use (46.6% vs 85.1%), hospitalization (40.9% vs 65.9%), intestinal resection (6.52% vs 20.8%), and mortality (4.6% vs 22%) compared with controls
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Franssen C, et al

Similar to the transcriptomic changes observed in the hypothalamus, we found that the conjugate prompted transcriptional patterns enriched for functional terms associated with synaptic transmission, including postsynaptic specialization and neuron-to-neuron synapse in the brainstem (Extended Data Fig

With 10% weight loss, we see improvements in glycemia, blood pressure and lipids