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Metformin, a biguanide, has been a cornerstone of type 2 diabetes pharmacotherapy for decades, with an established safety profile and extensive clinical experience
Slowed gastric motility at 15 mg can lead to constipation, particularly if fluid and fiber intake are inadequate
Data extraction and bias assessment were performed independently by multiple reviewers
The dose-response curve that your healthcare provider carefully calibrated when setting your starting dose no longer applies in the same way
Discussing lifestyle factors, including alcohol intake, diet, and physical activity levels
No medical or veterinary claims are made
