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4,207,208 The resultant neuronal hyperexcitability and microglial activation lead to chronic neuropathic pain

doi: 10.1016/j.obmed.2022.100456

They can be useful for breakthrough constipation but should be used under medical supervision if needed long-term

(2) Lifestyle factors: smoking status (including tobacco use, nicotine dependence, personal history of nicotine dependence, and alcohol-related disorders)

Data analysed by paired two-tailed Students t-test ( j - m ), unpaired two-tailed Students t-test ( p and r ), one-way ANOVA, multiple comparison, Bonferroni post hoc test ( h ) and two-way repeated measures ANOVA to assess main effects of treatment ( c , d and s - v )