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In a study published in NEJM SURMOUNT 5*, an international comparative open-label, controlled trial, adult participants with obesity but without type 2 diabetes the 2 agents were compared in maximally tolerated recommended doses

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Solid-Phase Peptide Synthesis (SPPS) of: A tetrapeptide extension (Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH) A C18-fatty acid linker with Glu-2xAEEA (PEG-based) Chemical Coupling of the components via NHS/DCC activation, followed by RP-HPLC purification and lyophilization