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GLP-1 receptor agonists, the class of drugs that includes semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound), are the most important class of medications to emerge in decades.

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Participants received diet (500kcaldeficit per day) and exercise counseling during 2-week run-in, before being randomly assigned (with a telephone or web-based system) to once-daily subcutaneous liraglutide (1.2, 1.8, 2.4 or 3.0mg, n=9095), placebo (n=98) or open-label orlistat (120mg 3, n=95)