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[DOI] [PubMed] [Google Scholar] 40.Li X., Zhang D., Vatner D.F., Goedeke L., Hirabara S.M., Zhang Y., Perry R.J., Shulman G.I

When it comes to the impact of GLP-1RAs on lipid metabolism of differentiated adipocytes, controlling expression of fatty acid synthase (FASN) and adipose triglyceride lipase (ATGL) enzymes is a significant issue [133]

These practices may be due to medical providers having biases about which patients will be able to afford certain medications, or about the effectiveness of medications in different patient groups. And again, not all insurance companies will cover them, and even if they do, co-pays and out-of-pocket costs can be prohibitive

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More recently, attention has shifted from the gut to these drugs effects in the brainspecifically, systems that regulate motivation, reward, and behavior