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However, compounds in which the S 2 -supplementing piperazine group was either replaced with a 3-aminopyrrolidine counterpart or eliminated regained DPP-2 binding ability

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GSEA enrichment analysis further demonstrated that the RA group showed significant enrichment and activation in biological processes such as osteoclast differentiation, cellular response to IFN, cellular iron ion homeostasis, and ferric iron binding (Fig