surmount-1 tirzepatide non-diabetic obesity trial weight loss Tirzepatide for Obesity: Highlights from the SURMOUNT-1 Tirzepatide as Compared with Semaglutide

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On side effects: GI events were somewhat higher in the tirzepatide arms at the highest doses, consistent with a stronger gastric-emptying effect from the dual GIP and GLP-1 mechanism

Additionally, the medication led to decreases in various factors associated with an increased risk of heart and metabolic diseases, including blood pressure, visceral adiposity, and circulating triglycerides