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First approved as the iPLEDGE Program in 2005, then as the iPLEDGE REMS (Risk Evaluation and Mitigation Strategy) in 2010, it established a centralized system for prescribers, pharmacies, and patients to manage patient risk, regardless of which isotretinoin product is being used

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Home monitoring is preferred because office readings can be elevated due to anxiety

58 These adipokines are involved in many biological processes, such as reducing oxidative stress, 59 improving fibroblast vitality, 60 and stimulating collagen synthesis and angiogenesis

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