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Wegovy followed in the US in 2021, and in the EU in 2022

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Sustained Exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes

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One well-documented interaction is with certain anti-epileptic drugs: high-dose pyridoxine may reduce the plasma levels of phenytoin and phenobarbital by enhancing their hepatic metabolism, potentially diminishing their anticonvulsant efficacy