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There are strict eligibility criteria

2024 Jan 15;17:227-230

Some patients experience plateaus after 34 months, when their dose stabilizes and appetite naturally normalizes somewhat

Table 1 shows a summary of their frequency of occurrence in phase III clinical trials
doi: 10.1208/s12248-016-9954-6 11 MylerHPedras-VasconcelosJPhillipsKHottensteinCSChamberlainPDevanaryanVet al

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