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Objective To determine whether the use of glucagon-like peptide-1 (GLP-1) receptor agonists is associated with an increased risk of suicidal ideation, self-harm, and suicide among patients with type 2 diabetes compared with the use of dipeptidyl peptidase-4 (DPP-4) inhibitors or sodium-glucose cotransporter-2 (SGLT-2) inhibitors

The results of the PIONEER-3 trial have now been published in the renowned journal Journal of the American Medical Association (JAMA) and are said to be trend-setting for future therapy of type 2 diabetes.

Bifidobacterium infantis produces the postbiotic acetate, and interacts with Akkermansia and Butyricum to promote an ecosystem in the gut that naturally boosts GLP-1

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It also encourages feelings of fullness, which can help reduce cravings and support consistent, long-term wellness as part of a balanced lifestyle

This Comment highlights emerging evidence and advocates for clinical strategies that prioritize muscle preservation to ensure the long-term success and safety of pharmacological weight management.