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Whether adding cagrilintide preserves more lean mass than retatrutide alone or whether the added satiety drives more lean-mass loss by reducing protein intake further is unknown

There are some important contraindications for taking GLP-1 medications: a severe allergic reaction to a GLP-1 medication in the past a history of pancreatitis pregnancy or breastfeeding a history of medullary thyroid cancer or multiple endocrine neoplasia type 2 in yourself or an immediate family member Finally, cost and access need to be considered

Some patients report reduced hunger and earlier satiety within the first week of treatment, though this varies considerably among individuals

They promote powerful GLP-1 appetite changes that quiet the non-physiological food noise, meaning you eat because your body needs nourishment, not because of compulsive thoughts or external cues

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