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Nevertheless, they will need to understand how to best capture this opportunity early on (while there is limited competition) by working with local regulators and funders to increase access to the drugs and by expanding production to meet demand

2025: Novo Nordisk announced positive Phase 3 ESSENCE trial results for semaglutide in early Alzheimer's disease, reporting statistically significant slowing of cognitive and functional decline a breakthrough data package that could establish GLP-1 therapy as a neuroprotective agent and open an addressable market of 6.5 million Alzheimer's patients in the U.S

Key References Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] [41].Meier JJ

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These results may have limited generalizability due to bias introduced by the studys design, including the treatment setting (ie, a neuroophthalmology clinic) and potential worse baseline health in patients taking semaglutide compared with matched controls