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Description
Repurposing anti-diabetic drugs for the treatment of Parkinson's disease: Rationale and clinical experience

All GLP-1 RA labels mention to monitor for pancreatitis signs

Data from numerous clinical trials primarily evaluating the antihyperglycemic effects of multiple GLP-1 RAs have also revealed that changes in most CVD risk markers reported as secondary outcomes have been in favor of GLP-1 RAs treatment

This is a placebo-controlled study with a duration of 72 weeks (83)
Brief history of GLP-1 discovery and development GLP-1 was discovered during research into the incretin effect, which occurs when oral glucose consumption leads to increased insulin production compared to intravenous glucose administration (Kreymann et al

There is also evidence for mechanisms involving a reduction of neuroinflammation, an increase in synaptic functioning, as well as the restoration of brain pathways of insulin signaling that may lead to improved memory formation and therefore a positive effect in Alzheimers disease and Parkinsons disease 34
