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Apitegromab is the first of this class to seek FDA approval in spinal muscular atrophy ( The focus has shifted to their use in obesity, both alone an in combination with the backbone GLP- 1 RA ( The companies developing the medications for this indication are also interested in their use to sustain weight loss after stopping the GLP- 1 RA ( The medications targeting the myostatin-activin pathway act in different ways

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In general, you should shoot to keep a diet at least 200-300 calories below your TDEE

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