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The new indication is for use in combination with reduced-calorie diet and increased physical activity

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3e), suggesting an engagement with -cells that is consistent with activity at both the GIPR and GLP-1R 35,36

The FDA has allowed compounding of these medications during ongoing shortage designations, though patients should always verify their medication comes from a licensed source

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Table 3 summarizes the pooled data on the gastrointestinal adverse reactions observed in the SURPASS-1 to SURPASS-5 studies for T2D therapy in comparison to placebo (61)