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Katsiki N, Athyros VG, Karagiannis A, Mikhailidis DP

There is also the issue of price pressures from both public health systems and private insurers as the GLP-1 class continues to grow and more generic versions are introduced

[DOI] [PubMed] [Google Scholar] 37.Garber A, Henry R, Ratner R, Garcia-Hernandez PA, Rodriguez-Pattzi H, Olvera-Alvarez I, Hale PM, Zdravkovic M, Bode B LEAD-3 (Mono) Study Group

In a surgically induced-OA model in rats, liraglutide also attenuated rat cartilage degeneration through suppressing the release of inflammatory mediators and protected chondrocytes against endoplasmic reticulum (ER) stress and apoptosis induced by interleukin-1 (IL-1) or triglycerides [46]

Lastly, when excluding BMI and pre-existing diabetes from the propensity score model, we observed similar findings to completely unadjusted estimates, for both semaglutide and liraglutide

Therefore, issues exist with drug compliance, and the substantial food-drug interactions may potentially generate inconsistent effects in the real-world setting