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At the systemic level, GLP-1 RAs improve insulin sensitivity in peripheral tissues (muscle, adipose), reduce circulating free fatty acid flux to the liver, suppress hypothalamic appetite circuits to promote weight loss, and lower systemic pro-inflammatory cytokines (TNF-, IL-1, IL-6), thereby reducing the hepatic inflammatory milieu indirectly [7,26,30]

Clinical studies show that patients on GLP-1 medications experience an average reduction of 20-30% in overall calorie intake

Miras AD, Prez-Pevida B, Aldhwayan M, et al

Braster Q, Silvestre-Roig C, Hartwig H, Kusters P, Aarts S, den Toom M, et al