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Structures of the glucagon receptor (GCGR), the closest homolog of GLP-1R, have revealed key differences between the peptide-free and peptide-bound states, including an interesting -sheet motif in the peptide-free structure comprised of the stalk region and extracellular loop 1 ( ECL1) 9,14

Circ Res (2001) 89:44552

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It had also been discounted for the treatment of obesity because there was some prec-clinical evidence to suggest it was linked with weight gain

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