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Description
Naltrexone/bupropion (Contrave) is a medication that combines an opioid receptor antagonist (naltrexone) with a dopamine and norepinephrine reuptake inhibitor (bupropion)

We interrogated metabolite patterns in central glucose metabolic pathways, projecting differences in PBH onto a pathway map at each time point (Figure 2)

Currently, this medicine is undergoing stage 3 clinical trials, which are expected to conclude in May 2026

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For a detailed comparison of newer alternatives, see our guide on semaglutide versus tirzepatide

10.2337/db08-0958
