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These neuropods synapse and thus establish direct connections with vagal afferents, enteric glia, and efferent fibers, releasing neurotransmitters such as glutamate

In a combined multiple ascending dose (MAD) and Phase 2a study in people with type 2 diabetes over 41 days, the safety of cotadutide was confirmed (83)
Beta-blockers may mask symptoms of hypoglycaemia (e.g., tremor)

10.1161/CIR.0000000000000973 [DOI] [PMC free article] [PubMed] [Google Scholar] 48.Wilding JPH, Jacob S

Novo Nordisk says the Wegovy pill should be widely available starting in January

This degree of glucose lowering often enables patients to achieve their individualised HbA1c targets as recommended by NICE (typically 48 mmol/mol for most adults with type 2 diabetes, or 53 mmol/mol for those at risk of hypoglycaemia)
