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Most patients experience increased water retention and appetite within 3-5 days, though actual fat regain takes longer

They have come into the limelight after a large double-blinded study published in NEJM, showed an average 14.9% decrease in weight in obese patients given semaglutide on top of lifestyle modifications, compared to 2.4% in the control arm (see research summary at end)

The most commonly prescribed medications in this class include: Ozempic (semaglutide): Originally approved for diabetes, frequently prescribed off-label for weight loss Wegovy (semaglutide): FDA-approved specifically for chronic weight management Mounjaro (tirzepatide): Dual-action diabetes medication increasingly used for weight loss Trulicity (dulaglutide): Weekly injection for diabetes management Rybelsus (oral semaglutide): Oral form of semaglutide for diabetes treatment Serious Health Complications Linked to Weight Loss Drugs The weight loss effectiveness of GLP-1 medications may come at a significant health cost

Patients who use the Precision Peptide test often experience faster results and fewer dose adjustments, which translates to lower overall costs and more predictable outcomes

INDICATIONS FOR NOVEL ANTIDIABETIC MEDICATIONS GLP-1RAs and dual GIP/GLP-1 receptor agonists are approved for two main indications: T2DM and obesity

doi: 10.1111/apt.18138