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Early reports suggested a possible increase in thyroid tumors

Due to a short plasma half-life of native GLP-1, several synthesized GLP-1 receptor agonists (RAs) were developed for type 2 diabetes mellitus (DM) treatment

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However, the current literature reveals a lack of in vivo studies on specific GLP-1R agonists such as semaglutide, necessitating further research to elucidate its precise mechanisms and effects, particularly in cancer

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These include loss of muscle mass, nutrient deficiencies, metabolic dysfunction, digestive discomfort, and nausea