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13 Two meta-analyses of other GLP-1 RA CVOTs found that GLP-1 RAs were associated with greater rates of DR progression, but both studies found that the effect was driven by the extent of hemoglobin A1c reduction, rather than the medications themselves

The severity of this varies drastically from case to case, but the majority of birth defect related deaths are caused by congenital heart disease

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As in adults, the incidence in girls is double that in boys

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