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experimental administration of low-dose IL-6 into mouse muscle induces muscle atrophy [59, 60]

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2 mg: 4.6% (P = 0.002) SAFETY & TOLERABILITY GI AEs significantly at 8 & 16 mg ~30% dropout in high-dose arms Dysesthesia (18% in 16 mg group) reportedfirst time seen with s.c

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