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It is well-established that elevated peripheral insulin levels can modify insulin receptor expression and affect insulin sensitivity in skeletal muscle and adipose tissue (35)
And how does their staying power turn into effects like lower risk of stroke or improved osteoarthritis

those which make compounded drugs for individual patients, are subject to regulation by 21 USC 353a

It also led to substantial improvements in both blood pressure measurements and lipid profiles

Cells 11 , 1553 (2022)
This is a genuine safety issue