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Conditional weighted residuals (CWRES) were used as a diagnostic tool to identify outliers, and an additional 24 concentration values (23 in the one-compartment model) were excluded from the final dataset as they were associated with CWRES greater than 6 in order to limit bias from influential data items

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This interaction is particularly relevant in patients at risk for folate deficiency, such as those with malabsorption disorders, chronic alcohol use, or those taking medications that interfere with folate metabolism

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