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And there are many reasons for this, including cost considerations, side-effect management, access considerations, and a general interest in GLP-1 therapies

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Injecting too deep (into muscle) or too shallow (into the dermis) changes absorption kinetics

However, current fluorescent imaging techniques may underestimate brain penetrance, and better techniques will be needed to get a fuller picture of which GLP-1 receptors are reached by systemically administered GLP-1R agonists