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You need to do whats called a randomized trial, where you give half of people a drug like semaglutide and half of the people not, then you follow them to see if there are lower rates of depression

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Contraindications typically include: Personal or family history of MTC or MEN 2 Known hypersensitivity to the medication Pregnancy or plans to become pregnant The Importance of Medical Supervision This information is not a complete list of side effects, risks, or precautions

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This effect was then shown to be mimicked by GLP-1 that acted on the same receptor (94)

However, for optimal results, we recommend avoiding strenuous exercise, excessive sun or heat exposure, and refraining from touching or massaging the treated area for 24 to 48 hours