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Male C57BL/6J mice typically develop more severe hyperglycemia and insulin resistance when fed high-fat diets compared to females, allowing for a more pronounced diabetic phenotype within our experimental timeframe

For Tucson residents, semaglutide also improves metabolic markers beyond weight alone

The only difference is the FDA-approved indication (type 2 diabetes versus chronic weight management)

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Strengths of STEP 5 include the high rates of adherence to treatment and completion of the trial (which contributed to consistency in findings between the two estimands)