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Methods Linkage Disequilibrium Score Regression (LDSC) was utilized to assess the genetic correlation between T2D and SA

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Results For the first time, it was highlighted: (a) the role of TIR in the activation of the pAkt/CREB/BDNF pathway and the downstream signaling cascade

Methods This narrative review is based on a comprehensive analysis of the supplied literature set, prioritizing high-level evidence from systematic reviews, meta-analyses, clinical guidelines, and key original studies published between 2021 and 2025