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Description
Glucagon-like peptide-1 receptor agonists (GLP-1 RA) entered clinical practice in the late 1990s as diabetes treatments, and decades of research have now validated their effectiveness for weight management

Some patients need higher doses to achieve meaningful appetite suppression

Ozempic requires you to be over 18 and have poorly controlled type 2 diabetes, whereas for Wegovy, youll need to meet particular body mass index (BMI) requirements
Benefits include: Sustained weight loss when combined with healthy lifestyle changes Blood sugar management for patients with type 2 diabetes Reduced cravings and better appetite control Common Side Effects Common side effects may include nausea, diarrhea, or constipation

GLP-1 slows digestion, signals fullness to the brain, and helps regulate insulin

Unfortunately, this synergy is lost in prolonged hyperglycaemic states due to selective dysfunction in GIP signallingdownregulation of GIPR mRNA and accelerated receptor degradationwhereas sensitivity to GLP-1 remains intact [22, 23]
