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Tirzepatides dual GLP-1R and GIPR agonism may confer distinct anti-inflammatory effects, some of which persist even when neuronal GLP-1R signaling is impaired

The discourse drones on, but I still have a disease to manage and choices to make

These formulations prolong the PK profile of both of these preparations to allow QW administration [3]

Existing extended-release options, like weekly formulations of semaglutide and dulaglutide, have reduced injection frequency, and future innovations may include monthly formulations or implantable devices that deliver continuous therapy

doi: 10.1210/clinem/dgag051

While laboratory findings and observational studies suggest potential benefits against the biological drivers of dementia, results from large clinical trials in people with established Alzheimers are still inconclusive