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In rodent models of diabetic neuropathy, GLP-1 receptor agonists have demonstrated a reduction in oxidative stress and inhibition of pro-inflammatory cytokines, both of which are implicated in neuropathic pain [16]

Use single-agent reninangiotensin system inhibitors at maximally tolerated doses and, when appropriate, sodium-glucose cotransporter-2 inhibitors and finerenone to slow the progression of DKD

However, it may take several months to achieve significant weight loss

Lcells are distributed in an increasing gradient along the length of the gastrointestinal tract, occurring at low frequency in the duodenum, increasing in the jejunum and peaking in the ileum and colon (Gribble & Reimann, 2021
Completion gastrectomy could be considered in patients with postsurgical gastroparesis who remain markedly symptomatic and fail medical therapy

A systematic review described other risk factors for the development of PBH, which are summarized in Table 2 [12]
