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When they do this, they help protect brain cells in different ways: They help clear out toxic proteins

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Possible integrative actions of leptin and insulin signaling in the hypothalamus targeting energy homeostasis

Zhou et al., 2025
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In mice fed high-fat diet (HFD) or high-fat high-cholesterol (HFHC) diets for 12 weeks, hepatic lactate levels and GPR81 expression were elevated
