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Collectively, these mechanisms optimize cardiac energy metabolism, mitigate oxidative stress, and support overall cardioprotection

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More recently, metabolic cage studies have confirmed that the increased oxygen consumption and energy expenditure effect of OXM is mediated through glucagon receptor signalling (39, 40)

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Through preclinical and phase I clinical trials, AMG 133 has demonstrated significant weight reduction and improvement in various metabolic parameters, paving a new path for the treatment of obesity and other related metabolic diseases

In vitro stability assay with high glutathione concentration GLP-1MK-801 was dissolved in dimethyl sulfoxide at a concentration of 0.25 mM and diluted with a solution of 200 mM glutathione in PBS, pH 7, such that the final concentration of GLP-1MK-801 in the assay was 100 M