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These label expansions unlocked new pathways for coverage, and by early 2025 the proportion of Medicare patients with diabetes or obesity initiating GLP-1 therapy rose sharply

The most used medications were semaglutide (54%), liraglutide (39%), and tirzepatide (7%)

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It also raises the risk of sarcopenia the age-related loss of muscle mass and function that contributes to frailty, falls, and reduced quality of life

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The focus remains on documenting how GLP-1 programs are defined, compared, and positioned as a distinct care model, using structural explanations rather than outcomes or treatment guidance.