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When you block the pathway that makes cholesterol, you also block production of CoQ10

The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk

SheehanAGoldfineABajwaMWolfsDKozukaCPiperJet alPramlintide for post-bariatric hypoglycaemia

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Furthermore, in January 2025, the FDA approved semaglutide (Ozempic ) for reducing the risk of kidney failure and disease progression in patients with diabetes and chronic kidney disease (CKD), making it the first GLP-1 agent indicated for the treatment of CKD (Perkovic et al., 2024)

This stems from altered enterohepatic circulationwithout a gallbladder, bile flows continuously rather than in controlled pulses, amplifying GLP-1's effects on intestinal transit