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While semaglutide is not a psychiatric medication, its effects on central GLP-1 pathways may create a biological environment more compatible with healthy cortisol regulation and emotional resilience

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These red flag symptoms may indicate serious cardiovascular events, severe hypoglycemia, or other acute medical conditions requiring urgent intervention

Additionally, patients on dual therapy would face doubled medication costs, doubled adherence burden, and no clinical evidence of superior outcomesmaking the risk-benefit calculation clearly unfavorable compared to optimizing a single agent

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