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From the earliest GLP-1 trials, it was clear that more was happening than a simple delay in gastric emptying promoting a feeling of satiety

Endocrinology 156 , 14531463 (2015)
Interestingly, the methylation level was negatively associated with DPP4 mRNA abundance and positively with plasma total/HDL-cholesterol ratio

However, there is an important caveat: research specific to perimenopausal women remains limited

[DOI] [PubMed] [Google Scholar] 106.Tang Y, Arbaugh B, Park H, Scher HB, Bai L, Mao L, et al

Diabetes mellitus (DM) significantly increases the risk of cardiovascular diseases and the overall and cardiovascular mortality, and it is a pro-atherogenic factor that induces atherosclerosis development and/or accelerates its progression through a multifactorial process
