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The Overlapping Biology of Addiction and Obesity Research shows SUDs share biological and psychological similarities with overeating and obesity, with both involving dysregulation of the brains reward system (Srinivasan et al., 2025)
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Evidence for separate roles Several lines of evidence support the notion of distinct roles for peripheral and central GLP-1 in appetite regulation: Differential breakdown: Peripheral GLP-1 has a very short half-life in the blood (around two minutes) due to enzymatic degradation

Regular detoxification may also support overall gut health and enhance nutrient absorption

Research shows that your food choices stimulate GLP-1 production during digestion

Common side effects include: Less common but more serious risks include: Just like any other weight loss treatment, semaglutide is not right for everyone, but for the right person, it can do wonders
