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Regulation of androgen synthesis affects follicular development and ovarian function through multiple pathways: Androgen-promoting pathways: IRS-PI3K/cAMP/PKA, MAPK/ERK (via FGF13/LH/CYP17), NF-B (via TNF- activation/CYP17 up-regulation), and miR-130b-3p (targeting MAPK1/PI3K) all promote androgen production

Pricing reflects cash pay on a multi-month plan

Phase 3 trial completion timeline Seven Phase 3 trials are expected to report results during this year

Its essential for patients to follow the specific dosing and administration instructions provided by their healthcare provider to ensure the safe and effective use of GLP-1 agonists

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Patients with Significant Liver Involvement: Those diagnosed with hepatic steatosis (fatty liver) or early-stage MASH, due to the potent anti-fat effects of the glucagon component on the liver