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The manifestations of mitochondrial dysfunction in AD mainly include increased oxidative stress and ROS production,152,153 mitochondrial DNA damage,154 mitochondrial respiratory injury,155 and calcium abnormalities.156 Mitophagy,157 mitochondrial dynamics,158 and mitochondrial biogenesis158 are also affected in patients with AD, ultimately resulting in the accumulation of dysfunctional mitochondria and mitochondrial fragmentation

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