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They have been studied in heart failure and kidney disease, and empagliflozin in particular is one of what cardiologists now call the "Fantastic Four" drug classes in the treatment of heart failure with reduced ejection fraction

For patients who want metabolic benefits without significant weight loss, Sinclair recommends doctor-supervised microdosing

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doi: 10.3389/fnagi.2026.1851072 Received 09 April 2026 Revised 18 May 2026 Accepted 20 May 2026 Published 05 June 2026 Volume 18 - 2026 Edited by Scott E