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Description
First appearance in Japan

260 In patients with UC, the Wnt/-catenin pathway is often abnormally activated, resulting in abnormal proliferation and differentiation of intestinal mucosal epithelial cells, which in turn triggers an inflammatory response and tissue damage

Expert Opin Drug Discovery (2014) 9:122351

He is receiving a maximal daily dose of metformin extended release (2000 mg
and that any discrepancies from the study as planned and registered have been explained

Watson, K