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Comparative Pharmacology: Benchmark efficacy against dual agonists like Tirzepatide to quantify the added benefit of glucagon receptor activation on metabolic rate and fat oxidation

Remarkably, in our GLP-1RFab7F38 structure, since no peptide ligand is bound to the orthosteric pocket, the peptide-binding groove of the ECD is juxtaposed with the TMD interacting with ECL1 and ECL3

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Taylor, D., Lunny, C., Wong, T., Gilbert, M., Li, N., Lester, R., Krajden, M., Hoang, L., & Ogilvie, G

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