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Quick Answer: When semaglutide gets warm beyond recommended storage temperatures, the peptide structure denatures, reducing medication potency and therapeutic effectiveness without necessarily causing visible changes

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Pregnancy itself changes medication metabolism and transfer across the placenta, adding another layer of safety concern

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Furthermore, tirzepatide significantly lowered cardiac troponin T levels compared with placebo, indicating reduced myocardial injury, along with a concurrent decline in NT-proBNP levels