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Hyperchloremic, non-anion gap, metabolic acidosis (hyperchloremic acidosis) is associated with topiramate

These findings support a neuroprotective effect of GLP-1 agonists, likely mediated by mitochondrial preservation [45]

FIGURE 3 Secondary outcomes Similarly, the risk of all-cause mortality alone was lower in the tirzepatide group, with 45 events (incidence rate: 1.0 per 100 person-years) compared to 119 events (incidence rate: 1.9 per 100 person-years) in the control group (HR, 0.52

This helps minimize side effects, such as nausea, which can occur when starting the medication
